**Some programs are limited. Please read solicitations carefully and consult your Office of Research for specifics, such as limited applications through your university and internal application deadlines.**

Using the Rules of Life to Address Societal Challenges (URoL:ASC) will support use-inspired research that builds on knowledge from previous investments in the NSF "Big Ideas", including in the Understanding the Rules of Life program. The Big Ideas were designed to position the Nation at the cutting edge of global science and engineering by bringing together diverse disciplinary perspectives to support convergent research (see details here). The goal of the Understanding the Rules of Life Big Idea was to developpredictive understanding of how key properties of living systems emerge from interactions of factors such as genomes, phenotypes, and evolving environments. Examples of projects that have examined some of these rules can be found here. Following from the fundamental principles revealed from these and related projects, an important goal of the current solicitation is to use the predictive capability of rules of life to address some of the greatest challenges we currently face as a society.

Through use-inspired research using convergent, multidisciplinary approaches, URoL:ASC seeks to apply lessons learned from studying rules of life across a broad array of living systems to tackle pressing societal concerns. These concerns include but are not limited to: climate change and associated risks, including geohazards, extreme events, and loss of biodiversity; environmental degradation, including impacts on land and water resources; inequalities in availability of and access to essential natural assets; lack of sustainability, including for food, energy, and waste production; and threats from pandemic disease, among others.

Estimated Total Program Funding: $28,000,000
Expected Number of Awards: 10-15

Application Deadline: February 15, 2023 by 5:00 pm submitter's local time